Health: Mid-Life Health Tied to Late-Life Alzheimer’s Risk/Story: You Must Bring A Hat!

Study: Mid-Life Health Tied to Late-Life Alzheimer’s Risk People with risk factors for heart attack and stroke such as obesity, high blood pressure, diabetes, high cholesterol, and smoking are also more likely to develop changes in the brain that can lead to Alzheimer’s disease, a new study shows. These risk factors previously have been linked to higher odds of dementia, cognitive decline and Alzheimer’s disease, but it’s been unclear exactly how. Researchers theorize the risk factors might reduce vascular clearance of amyloid protein from the brain. A team of researchers examined data from a 25-year period of 346 people who were dementia-free and had been evaluated for vascular risk factors and markers. They found that people who smoked, were obese, or had high blood pressure, diabetes or high cholesterol in their 50s were more likely to develop high levels of brain amyloid levels, which are protein fragments associated with Alzheimer’s disease, while in their 70s. However, the study did not find a connection between later-life vascular risk factors and later-life brain amyloid deposits. The results show that mid-life behaviors can impact our brain composition later in life, says neurologist Jagan Pillai, MD, PhD. Dr. Pillai did not take part in the study. Each heart risk factor by itself may not be enough to increase the risk of Alzheimer’s disease, but having a number of these risk factors at the same time appears to be associated with a higher risk, he says. “Having more than one vascular risk factor such as diabetes, high blood pressure, obesity or smoking history does translate into increased amyloid burden later,” he says. https://health.clevelandclinic.org/study-mid-life-health-tied-to-late-life-alzheimers-risk/?utm_campaign=cc%20posts&utm_medium=social&utm_source=twitter&utm_content=092218%20brain&cvosrc=social%20network.twitter.cc%20posts&cvo_creative=092218%20brain Story: You Must Bring A Hat! By Simon Philip